Diet-induced NASH mouse model
Physiogenex's proprietary diet-induced (DIN) NASH mouse model. Evaluation of NASH drug efficacy in an obese and insulin-resistant environment.
The Physiogenex independently developed diet-induced NASH mouse model involves feeding a high-fat, high-cholesterol diet, along with the addition of fructose to drinking water. This induces severe liver damage, obesity, and insulin resistance. As a result, liver fat and hepatocyte ballooning appear by the 16th week of feeding, and severe liver complications (inflammation and fibrosis) develop by 25 weeks of age. Additionally, the administration of the FXR agonist obeticholic acid, which is related to NASH, results in observed reductions in obesity, insulin resistance, fatty liver, and ballooning at both 16 and 25 weeks of age. This experimental system allows for the efficacy evaluation of drugs using obeticholic acid as a control, set against a background of obesity and insulin resistance that resembles the histopathological features of human NASH. Furthermore, there are efficacy evaluation data and academic papers (PDF) using Elafibranor (GFT505) as a control drug. For more details, please contact us. *Inquiries can also be made through our website. We will respond promptly. (Search for "Clea Japan" at http://www.clea-japan.com/)
- Company：日本クレア
- Price：Other
